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Figure 2.
Figure 2. Conformational changes in MAM and TCR upon complex
formation. (a) Superposition of the MAM–HLA-DR1/HA complex
(green) determined in our earlier study^13 onto its counterpart
(red) in the ternary complex. The MAM CTD is not included in
superposition. (b) Superposition of the MAM CTD in the previous
MAM–HLA-DR1/HA binary complex^13 onto its counterpart (red) in
the ternary complex. (c) Superposition of the ligand-free TCR-2C
(ref. 2), and TCR-2C in complexes with H-2K^b MHC I with an
agonist^14 and a superagonist peptide^15, onto TCR T7 in our
ternary complex. Light gray, non-CDR regions; purple, CDRs of V
 ;
green, T7 V  ;
lime, free 2C; pink, 2C with agonist peptide; cyan, 2C with
superagonist peptide.
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