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Figure 2.
Figure 2. Optimal superimposition of the MMP-13/TIMP-2 complex
with the MMP-14/TIMP-2 complex.^25 CdMMP-13 is shown in surface
representation with some residues indicated by blue labels, and
MMP-14 is omitted for clarity. The stereo views show the
detailed interactions of some TIMP-2 edge loops (orange) of the
MMP-13/TIMP-2 complex and compare them with the TIMP-2 loops in
the MMP-14/TIMP-2 complex (green). (a) Front view towards the
left-hand side surface of cdMMP-13. The distal parts of the
sA-sB loops of both TIMP-2 molecules are shown as stick models.
(b) Front view towards the right-hand side surface of cdMMP-13
showing the interactions of the C-terminal parts of TIMP-2 with
MMP-13 (surface) in comparison with the equivalent TIMP-2
segments in the MMP-14/TIMP-2 complex. Figure 2. Optimal
superimposition of the MMP-13/TIMP-2 complex with the
MMP-14/TIMP-2 complex.[3]^25 CdMMP-13 is shown in surface
representation with some residues indicated by blue labels, and
MMP-14 is omitted for clarity. The stereo views show the
detailed interactions of some TIMP-2 edge loops (orange) of the
MMP-13/TIMP-2 complex and compare them with the TIMP-2 loops in
the MMP-14/TIMP-2 complex (green). (a) Front view towards the
left-hand side surface of cdMMP-13. The distal parts of the
sA-sB loops of both TIMP-2 molecules are shown as stick models.
(b) Front view towards the right-hand side surface of cdMMP-13
showing the interactions of the C-terminal parts of TIMP-2 with
MMP-13 (surface) in comparison with the equivalent TIMP-2
segments in the MMP-14/TIMP-2 complex.
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