Figure 2.
Figure 2. Overview and specific interactions of the CR1-BoNT/A1
co-crystal. (a) Overall view of BoNT/A1 (yellow) in complex
with the CR1 Fab with its light and heavy chains in magenta and
green, respectively. (b) Overview of the CR1-BoNT/A1 interface,
with the antigen contacting loops (H1, H2, H3, L1, L2 and L3)
and toxin -strands
indicated. (c) Detailed view of contacts between CR1 Fab and
BoNT/A1. A cartoon representation of BoNT/A1 is shown with
carbons (yellow), nitrogens (blue) and oxygens (red). Amino acid
contacts are indicated by magenta (V[L]), green (V[H]) and black
(BoNT/A) numbering. V[L], variable light chain; V[H], variable
heavy chain.
The above figure is reprinted
by permission from Macmillan Publishers Ltd:
Nat Biotechnol
(2007,
25,
107-116)
copyright 2007.
-strands
indicated. (c) Detailed view of contacts between CR1 Fab and
BoNT/A1. A cartoon representation of BoNT/A1 is shown with
carbons (yellow), nitrogens (blue) and oxygens (red). Amino acid
contacts are indicated by magenta (V[L]), green (V[H]) and black
(BoNT/A) numbering. V[L], variable light chain; V[H], variable
heavy chain.