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Figure 2.
Figure 2. Structure of full-length SUMO-1 bound to SENP1 C603A.
(a) SENP1(C603A)–SUMO-1-FL complex. Cyan, SENP1; purple,
SUMO-1-FL. SENP1 is effectively identical to earlier
descriptions. (b) Superposition of
SENP1(C603A)–RanGAP1–SUMO-1 complex with
SENP1(C603A)–SUMO-1-FL complex. In the superposed
RanGAP1–SUMO-1 complex, RanGAP1 is in red, SENP1 is in dark
blue and SUMO-1 is in turquoise. Isopeptide bond is depicted as
in Figure 1a. (c) Detail of the complex in a, with SENP1 in dark
blue and carbons of SUMO-1-FL in pink. Residues mentioned in the
text are indicated. Dotted line denotes hydrogen bond. (d) The
same cis arrangement of nitrogens is seen in the
SENP1(C603A)–SUMO-1-FL processing complex and in the
SENP1(C603A)–RanGAP1–SUMO-1 deconjugating complex (colored
as in b and c).
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