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Figure 2.
Figure 2. Binding mode of HBY 097 to the
Lys103Asn/Tyr181Cys double mutant RT. (a) Stereo view of the
(2|F[o]|–|F[c]|) electron density (contoured at 1.2σ)
covering HBY 097 (cyan) and Cys181 (magenta). The dotted line
represents the hydrogen bond between the thiol group of Cys181
and HBY 097. Electrostatic potential surface^62 showing the
NNIBP region of (b) the double mutant RT/HBY 097 and (c)
wild-type RT/HBY 097^13 structures.
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