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Figure 2.
Fig. 2. Stereo-diagrams comparing the NNRTI binding sites
of wild-type and mutant RTs for the following complexes: (A)
Lys101Glu and nevirapine, (B) Glu138Lys and nevirapine, and (C)
Glu138Lys and PETT-2. The thinner and thicker bonds show the CA
backbone and side-chains with wild-type RT coloured orange and
the mutant RTs coloured blue, respectively. Inhibitors and water
molecules are shown in ball-and-stick representation and
coloured red for wild-type RT and cyan for mutant RTs. For
clarity, the side-chains at the site of mutation are shown in
magenta for wild-type and green for the mutants. Hydrogen bonds
linking drug to protein and drug to water molecules are marked
in dashed lines, coloured yellow for wild-type and blue for
mutant RTs.
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