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Figure 2.
FIGURE 2. Structure of the  4- 5 loop of SEI. A,
electron density from the final 2F[o] – F[c] map at 2.0
Å resolution showing SEI residues 70–75 in a stick
representation. Carbon atoms are green, nitrogen atoms are blue,
oxygen atoms are red, and the sulfur atom is yellow. B,
superposition of SEI (cyan) onto SPEC (red) in the SPEC·V
2.1
structure (38). Steric clashes are observed between the 4- 5 loop of
SEI (blue) and CDR1 (yellow) and CDR2 (brown) of V 2.1. CDR3
is purple; hypervariable region 4 (HV4) and framework region 3
(FR3) are green. The 4- 5 loop of SPEC is pink.
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