Figure 2 - full size

Figure 2. Figure 2. FXI activation. (a) Ribbon diagrams representing zymogen activation by superposition of the FXIa structure (green; PDB entry 1ZJD) and the zymogen protease domain (yellow). The region of largest conformation change is the activation loop comprising residues 376–370. Ile370 side chain is colored purple in both structures. Active site Ser557 side chain is also shown. (b) Space-filling representation of the FXI dimer. White side chains, Arg369 and Ile370 from the activation loop; blue side chain, Lys252 and Lys253; red side chain, Glu66.

The above figure is reprinted by permission from Macmillan Publishers Ltd: Nat Struct Mol Biol (2006, 13, 557-558) copyright 2006.