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Figure 2.
Figure 2. Richardson Diagram of the Overlay of Active and
Inactive apo-CDK2
(A) Active apo-CDK2 is shown in yellow;
inactive apo-CDK2 is shown in blue. The differences in the
orientation of the N and C domains and in the large movement of
the T-loop upon cyclin binding can be observed upon overlay of
the active and inactive structures from residues 170–285.
(B) Electron density difference maps (2F[o] − 1F[c]) in the
ATP binding site of the CDK2/cyclin A/4 complex.
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