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Figure 2.
Fig. 2. Interface between IL-2R  and IL-2. Open-book
representation of the IL-2/IL-2R interface. The
electrostatic potential was mapped onto the molecular surface
and contoured at ±35kT/eV (blue/red). The interface
features a hydrophobic center, flanked by a large number of salt
bridges and other polar contacts. The strong electrostatic
component of this interaction serves to rapidly capture IL-2
and, thus, to dominate the k[on] rate of IL-2 binding to the
IL-2R.
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