Figure 2.
Figure 2: Anchoring points between the regulatory and catalytic
regions. a, The switchboard is formed by strands provided by
cNBD-B (dark green), the REM domain (orange) and the loop of the
helical hairpin (HP) of CDC25-HD (blue). Peptides are reduced to
polyglycine. Hydrogen bonding by main-chain atoms is indicated
by dotted lines. b, The REM domain (orange) interacts tightly
with the C-terminal helix of the helical hairpin (blue). Thick C
traces
highlight the parts of the switchboard shown in a. c, The ionic
latch between cNBD-B (green) and CDC25-HD (blue). CH, connecting
helix (see Fig. 1b).
The above figure is reprinted
by permission from Macmillan Publishers Ltd:
Nature
(2006,
439,
625-628)
copyright 2006.
traces
highlight the parts of the switchboard shown in a. c, The ionic
latch between cNBD-B (green) and CDC25-HD (blue). CH, connecting
helix (see Fig. 1b).