Figure 2 - full size

 

Figure 2.
Fig. 2. Details of p14·SF3b155 interface. (A) Hydrophobic core of the p14·SF3b155 interface. p14 is colored yellow, and SF3b155 peptide is colored blue. (B) Hydrogen-bonding network and salt bridges surrounding the hydrophobic core. p14 is colored yellow, and SF3b155 peptide is colored blue. Hydrogen bonds involved in secondary structural elements are omitted. (C) Surface representation of the p14·SF3b155 complex showing Y22 of RNP2 exposed within a surface pocket surrounded by conserved basic residues. p14 is shaded light gray, SF3b is shaded dark gray, Y22 is colored yellow, and R24, R57, R96, and K100 are colored blue.