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Figure 2.
FIGURE 2. Molecular details of the UL44-UL54 interface. A,
the connector loop of UL44 (white) and the UL54 peptide (brown)
are joined by an extensive network of hydrogen bonds (green
dots). Four intermolecular hydrogen bonds are formed between
main chain atoms of the connector loop (residues 133-137) and
the peptide (residues 1234-1238). Additional hydrogen bonds are
observed between the side chain of Gln^133 (yellow) of UL44 and
the main chain of the peptide and between the side chains of
Gln^51 and Lys^60 (light blue) of UL44 and the main chain of the
connector loop. Ile^135 (yellow) of UL44 forms a critical
hydrophobic anchor below the hydrogen-bonding network. For
clarity, only the side chains of Gln^51, Lys^60, Gln^133, and
Ile^135 are shown. B, Leu^1227, Phe^1231, and Tyr^1234 (magenta)
are part of a hydrophobic plug that packs against a hydrophobic
crevice composed of Val^136 (yellow) from the connector loop
(cyan) as well as hydrophobic and aliphatic side chains (green)
from the central  -sheet of UL44. C, the
molecular surface of UL44 reveals pockets that accommodate the
three-residue hydrophobic plug of UL54.
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