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Figure 2.
Figure 2 Comparison of PARNn with other members of the DEDD
family. (A) Structural comparison of the nuclease domain of
PARNn with those of  epsilon
186 and Pop2p. The DEDD core domains are colored yellow, cyan
and green for PARN, epsilon
186 and Pop2p, respectively, with the rest of the molecules
colored in pale gray. Bound nucleotides are shown in stick
model. (B) Structures of the active sites of PARNn, epsilon
186 of Pol III and the klenow fragment of Pol I. Bound
nucleotides are shown in stick model, catalytic residues in
ball-and-stick model and metal ions in CPK model colored with
magenta. (C) Solvent-accessible and electrostatic potential of
PARNn colored from blue (basic) to red (acidic). For simplicity,
only one subunit is shown. Left panel: the side view of the
electrostatic potential surface. Right panel: the top view of
the surface rotated about 90° around y axis relative to the view
in the left panel.
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