Figure 2.
Figure 2. SB27 TCR contacts at the interface. (a) 'Footprint'
of the SB27 TCR on the HLA-B^*3508-LPEP complex. There are
limited MHC-mediated contacts with the SB27 TCR on the gray
surface representation of the HLA-B^*3508 heavy chain. (b)
'Footprint' of the LC13 TCR in complex with HLA-B8-FLRGRAYGL,
showing the focus toward the carboxy-terminal end of the
peptide^5. (c) Closer view of the SB27 TCR contacts with the
HLA-B^*3508-LPEP complex. HLA-B^*3508 -helices,
light gray; peptide, orange; conformation of Gln155 as it
appears in the binary complex (HLA-B^*3508-LPEP)3, dark gray;
side chains from the triad of residues mediating
MHC-restriction, gold. CDR loop colors are as in Figure 1b.
The above figure is reprinted
by permission from Macmillan Publishers Ltd:
Nat Immunol
(2005,
6,
1114-1122)
copyright 2005.
-helices,
light gray; peptide, orange; conformation of Gln155 as it
appears in the binary complex (HLA-B^*3508-LPEP)3, dark gray;
side chains from the triad of residues mediating
MHC-restriction, gold. CDR loop colors are as in Figure 1b.