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Figure 2.
Figure 2. Crystal Structure of the mAPH in Complex with the
AR Protein AR_3a
(A) Stereo view of the AB heterodimer of
the mAPH/AR_3a complex. The mAPH is shown in orange, and the
AR_3a is shown in light blue. AR_3a binds to the C-terminal lobe
of the mAPH and stabilizes an inactive conformation.
(B)
Asymmetric mAPH pseudo-homodimer found in the crystal of the
mAPH/AR_3a complex.
(C) Symmetric wtAPH dimer found in the
wtAPH crystal.
(D) Stereo view of the superposition of the
mAPH hetereodimer AB (orange) and BC (light blue).
(E)
wtAPH in the kanamycin A bound form (PDB: 1L8T1L8T). ADP and
kanamycin A are labeled.
(F) mAPH/AR_3a AB heterodimer in
the same orientation as the wtAPH in (E).
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