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Figure 2.
FIG. 2. X-ray crystallographic results. A, a view of the
x-ray structure of 1 (yellow, with standard coloring for oxygen
and nitrogen atoms) in the active site of Cat G, represented as
a Connolly surface (green), at 1.85 Å resolution. B, a
view of the x-ray structure of 1 (yellow, with standard coloring
for oxygen and nitrogen atoms) in the active site of chymase,
represented as a Connolly surface (green), at 1.9 Å
resolution. C, a schematic representation of the interactions
surrounding the S[1] and S[2] subsites for 1·Cat G. D, a
schematic representation of the interactions surrounding the
S[1] and S[2] subsites for 1·chymase. For A and B,
certain amino acid residues and enzyme subsites are labeled. For
C and D, ligand 1 is shown in its approximate orientation in
each complex, with the amide bond that rotates  180°
highlighted in red. The hydrogen bonds are depicted by dashed
lines accompanied by the distances between the heavy atoms.
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