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Figure 2.
FIG. 2. The human Lox-1 tunnel. Stereoview of the tunnel
outer molecular surface viewed from the top (a; orientation
similar to Fig. 1b) and from the tunnel end (b; as in Fig. 1a).
The semitransparent tunnel molecular surface is colorcoded with
green for carbon, red for oxygen, and blue for nitrogen.
Selected residues and bound dioxane are shown as stick models.
c, stereoview of the interactions bound dioxane makes in the
Lox-1 tunnel including the 1.4 Å 2F[o]-F[c] electron
density map contoured to 1.0  . Hydrogen bonds are
represented by dotted lines and the electron density for dioxane
is colored dark blue for clarity.
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