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Figure 2.
FIG. 2. Comparison of the polypeptide folds of IIB^Mtl,
BPTP, and IIB^Chb. Ribbon diagrams showing two approximately
orthogonal views of IIB^Mtl (red)(A), BPTP (B), and IIB^Chb (C).
In panels B and C the regions of the polypeptide of BPTP and
IIB^Chb, respectively, that superimpose on IIB^Mtl are shown in
blue with the remainder in gray. Also shown in each case is the
location of the active site cysteine. Single-letter amino acid
abbreviations are used. For IIB^Mtl and BPTP (PDB accession code
1DG9 [PDB]
) (64), the C[  ]atoms of 81 residues
(sequence identity 12.3%) superimpose with an r.m.s. difference
of 1.9 Å; for IIB^Mtl and IIB^Chb (PDB accession code 1H9C
[PDB]
) (19), the C[ ]atoms of 74 residues
(sequence identity 8.1%) superimpose with an r.m.s. difference
of 2.0 Å. (The structural alignments are as follows:
residues 378-411, 411-417, 422-429, 429-444, 444-450, and
455-466 of IIB^Mtl superimpose on residues 6-39, 40-46, 83-90,
91-103, 111-117, and 146-157, respectively of BPTP; residues
378-385, 386-408, 409-420, 421-430, and 431-451 of IIB^Mtl
superimpose on residues 4-11, 11-33, 33-44, 48-57, and 61-81,
respectively of IIB^Chb).
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