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Figure 2.
FIG. 2. IBMX binding. Stereoview of the electron density
for IBMX bound to PDE4D2 (A) and PDE5A1 (B). The 2F[o] - F[c]
maps were calculated from the structures omitted IBMX and
contoured at 1.5  for PDE4D2 and 2.0 for
PDE5A1. C, chemical structure of IBMX. D, IBMX binding to the
active site of PDE4D2. The xanthine group stacks against Phe-372
and forms hydrogen bond with Gln-369 (dotted lines). E, IBMX
binding to the active site of PDE5A1.
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