Figure 2.
Figure 2: Stereo view of the active site of the PDE5 -sildenafil
complex. Sildenafil is shown as a stick model with carbon
atoms coloured yellow. Metal- and inhibitor-binding residues of
PDE5 are shown as stick models with carbon atoms coloured white.
The zinc (the bigger CPK model) and magnesium ions are shown in
orange and green, respectively. The amide moiety of the
pyrazolopyrimidinone group of sildenafil forms a bidentate
hydrogen bond with the -amide
group of Gln 817, which is well ordered by a hydrogen bond relay
involving Gln 817 to Gln 775, Gln 775 to Ala 767 and Gln 775 to
Trp 853. The model orientation is the same as in Fig. 1a.
The above figure is reprinted
by permission from Macmillan Publishers Ltd:
Nature
(2003,
425,
98-0)
copyright 2003.
-amide
group of Gln 817, which is well ordered by a hydrogen bond relay
involving Gln 817 to Gln 775, Gln 775 to Ala 767 and Gln 775 to
Trp 853. The model orientation is the same as in Fig. 1a.