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Figure 2.
Figure 2. Solution Structures of Mi2b-P2 and Structure
Comparisons with PHDs from WSTF and KAP-1(A) Ensemble of the
best 20 structures of Mi2b-P2. Structures are superimposed over
the backbone atoms (C^a, C', N) of residues 9-43 and 48-53
(residues 1-7 and 55-61, which are unstructured, are omitted for
clarity). The zinc-chelating side chains are shown in yellow and
green, and the zinc atom is shown in magenta. The L1 and L3
loops are shown in blue and red, respectively.(B) Ribbon diagram
of the lowest energy structure of Mi2b-P2, showing elements of
secondary structure as recognized in the program MOLMOL (Koradi
et al., 1996). Structures in (A) and (B) are shown as wall-eyed
stereo images.(C and D) Overlay of ribbon diagrams of the lowest
energy structures of Mi2b-P2 and the solution structure of the
PHDs from (C) WSTF and (D) KAP-1. Structures are superimposed
over the backbone atoms (C^a, C', N) of residues 9-43 and 48-53
in Mi2b-P2 and the corresponding residues in WSTF-PHD and
KAP-1-PHD, respectively. End terminal unstructured residues are
omitted for clarity.
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