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Figure 2.
Figure 2. The Structure of the Nogo Receptor Ligand Binding
Domain(A) Side view. The N-terminal cap domain (LRRNT) is
colored in purple, the leucine-rich repeats (LRR) are in cyan,
and the C-terminal cap (LRRCT) domain is in pink. The
high-mannose Asn-linked glycosylation sites are depicted as
bonds in yellow. The central Phe residues of the “spine” are
depicted as bonds in orange.(B) SIGMAA-weighted 2Fo − Fc
electron density contoured at 1.5σ, showing the spine of the
structure formed by a line of phenylalanine residues.(C) Face-on
view into the concave belly formed by the leucine-rich
repeats.(D) Structural superposition of NgR with the structure
of platelet glycoprotein Ibα, showing a conserved β finger
aside the concave binding face. To the right are the
superpositions showing the similarities and differences between
the LRRNT and LRRCT; note NgR does not contain the β switch
that glycoprotein Ibα uses for ligand capture.
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