Figure 2.
Figure 2 Crystal structure of Par6B(126 -253) bound to
Cdc42(Q61L) GMPPNP
at 2.1 Å resolution. Ribbon diagram with Cdc42 colored blue and
Par6 yellow (left and center images). A structure of the WASP
-Cdc42 complex (Abdul-Manan et al., 1999) is also shown on the
right, for comparison. The Switch I and II regions of Cdc42 are
colored red, the semi-CRIB motif of Par6 and the CRIB motif of
WASP are colored black, and the GMP-PNP/Mg2+(H[2]O)[2] moiety is
presented in ball-and-stick representation. A short region of
the PDZ domain of Par6 (residues 204 -208) that makes contact
with Cdc42 is highlighted in magenta. The center image is of the
complex rotated by 90° about the vertical axis. The black arrow
indicates the location of the PDZ ligand-binding pocket.
The above figure is reprinted
from an Open Access publication published by Macmillan Publishers Ltd:
EMBO J
(2003,
22,
1125-1133)
copyright 2003.
GMPPNP
at 2.1 Å resolution. Ribbon diagram with Cdc42 colored blue and
Par6 yellow (left and center images). A structure of the WASP
-Cdc42 complex (Abdul-Manan et al., 1999) is also shown on the
right, for comparison. The Switch I and II regions of Cdc42 are
colored red, the semi-CRIB motif of Par6 and the CRIB motif of
WASP are colored black, and the GMP-PNP/Mg2+(H[2]O)[2] moiety is
presented in ball-and-stick representation. A short region of
the PDZ domain of Par6 (residues 204 -208) that makes contact
with Cdc42 is highlighted in magenta. The center image is of the
complex rotated by 90° about the vertical axis. The black arrow
indicates the location of the PDZ ligand-binding pocket.