Figure 2.
Fig. 2. Adaptivity of the IL-2-binding surface. (a)
Structure of the complex of IL-2 and Compound 1, shown as a
surface representation of IL-2 (white and orange) and stick
representation of Compound 1 (green). The residues that comprise
the IL-2R -binding
hot spot are shown in orange. Residues contacting the molecule
are labeled. (b-d) Surface representation of three different
unliganded structures (21) (b) and Native I and II (c and d;
Table 1). Compound 1 is overlaid to emphasize the extent of
rearrangement that occurs in both of the unliganded structures
and in the liganded form. Movie 1 (RIGIMOL, W. L. DeLano)
highlights the dynamic nature of this site across this series of
structures.
-binding
hot spot are shown in orange. Residues contacting the molecule
are labeled. (b-d) Surface representation of three different
unliganded structures (21) (b) and Native I and II (c and d;
Table 1). Compound 1 is overlaid to emphasize the extent of
rearrangement that occurs in both of the unliganded structures
and in the liganded form. Movie 1 (RIGIMOL, W. L. DeLano)
highlights the dynamic nature of this site across this series of
structures.