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Figure 3.
Figure 3. Comparison of FERM F3 and PTB Domain
InteractionsStereo Cα plot comparing the F3 subdomain of talin
and the integrin sequence (red), the F3 subdomain of moesin and
the β strand of the C-terminal tail (green), and the PTB domain
of X11 with the β-APP bound (blue). The structures were
superposed by aligning the Cα atoms of 39 residues in the β
sandwich. The ligands are shown as thick lines. The tyrosine
sidechains of the NPxY motifs of integrin and β-APP are also
shown. For clarity, insertions in the X11 structure absent in
FERM domains are not shown. Residue numbering is for talin.
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