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Figure 3.
Figure 3. MIDAS StructuresStructures are from the I
domain:ICAM-1 complex (A), the pseudo-liganded high-affinity I
domain (B), the unliganded high-affinity I domain (C), the
unliganded intermediate-affinity I domain (D), and the wild-type
I domain (E) (1LFA) (Qu and Leahy, 1996). The keys to the color
scheme are shown below, with the ICAM-1 or ligand mimetic
molecule colored cyan in (A) and (B). The metal ions are colored
blue, water molecule and ligating side chain oxygen atoms are
colored red, and the chloride ion from the wild-type I domain
structure is colored orange. The MIDAS residues and Glu-34 from
ICAM-1 in (A) and Glu-272 from a lattice mate I domain in (B)
are shown as ball-and-stick models. Metal coordination and
hydrogen bonds are represented by solid black lines and gray
dotted lines, respectively.
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