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Figure 2.
Figure 2. (a) Ribbon representation of the FF domain with
the side-chains of the structural ensemble for the conserved
residues in the hydrophobic core of the domain. (b)
Structure-based sequence alignment of selected FF domains.
Proteins included are the WW/FF domain-containing proteins that
have been shown to bind to RNAP II CTD via their FF domains
(mouse HYPA/FBP11(Q9R1C7), Saccharomyces cerevisiae PRP40
(PR40_YEAST), human CA150 (O14776)), human RHOGAP 190-A (Q9NRY4)
and human RHOGAP 190-B (Q13017). Residues that are conserved in
50% of FF domains are indicated.
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