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Figure 2.
Fig. 2. Activation loops. The close structural
correspondence between the EGFRK A-loop (blue) and the A-loop
from the phosphorylated form of the insulin receptor kinase (33)
(gold) is shown. The hydrophobic interaction between Lys836 and
Tyr845 almost exactly reprises that between Arg1155 and Tyr1163
of p-IRK (underlined). The presence of four glutamate residues
in this part of EGFRK has been suggested as a cause for its
intrinsic catalytic activity.
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