|
Figure 2.
Fig. 2. Stereo representation of structural changes at the
NH[2]- and COOH-terminal side of VWF-A1. The bottom face of the
A1 domain, as observed in the complex with GpIb  , is shown
in space-filling representation with the NH[2]- and
COOH-terminal peptides shown as C -traces in
yellow. The position of the  finger of
GpIb is given
by a C -trace in
green. The C -traces of
the NH[2]- and COOH-terminal peptides of the uncomplexed,
wild-type (wt) A1 domain (7) are shown in red. Residues with
known gain-of-function mutations yielding a type 2B von
Willebrand disease phenotype are shown either in ball-and-stick
representation in the wt NH[2]- or COOH-terminal peptides or
colored blue in the space-filling model of the bottom face. In
full-length VWF, flanking peptides of A1 possibly shield the
binding site of the finger of
GpIb .
|
