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Figure 2.
Fig. 2. (A) The structure (PDB ID code 1EXN) determined
for T5 5' nuclease showing the helical arch (red backbone),
divalent metal ions (gray spheres), and space-filling
representations of selected lysine (blue) and arginine (cyan)
residues. (B) Original DNA-binding model proposed by Ceska et
al. (8). The duplex parts (I and II) of the substrate lie across
a slightly concave and positively charged region of the protein.
In this model residues K241, K215, and R216 contact duplex I,
and R172 contacts duplex II.
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