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Figure 2.
Fig. 2. PDZ1 interaction with the  [2]AR and
PDGFR carboxyl termini. A and B, stereo images of the hNHERF
PDZ1 binding pocket bound to the [2]AR (A)
and PDGFR (B) carboxyl-terminal ligands. Carbon, oxygen, and
nitrogen atoms are shown in black, red, and blue, respectively.
Water molecules are depicted as green spheres, and hydrogen
bonds are shown as dashed lines. C and D, two-dimensional
representations of the interactions observed between the hNHERF
PDZ1 residues (orange) and [2]AR (C) or
PDGFR (D) peptide ligands (purple). Dashed lines denote hydrogen
bonds, and numbers indicate hydrogen bond lengths in Å.
Hydrophobic interactions are shown as arcs with radial spokes. C
and D were generated using LIGPLOT (38). E, superposition of the
hNHERF PDZ1 bound to CFTR (yellow), [2]AR
(blue), and PDGFR (pink) peptide ligands. For clarity, the 2 strand and
 2 helix of
the PDZ1 domain are shown as ribbon diagrams, and only the C^
 traces
are shown for the remaining PDZ1 main chain. Side chains of the
peptide ligands and the PDZ1 residues Asn22 and Glu43 are shown
as ball-and-stick models.
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