Figure 2.
Figure 2: Structural comparison of the Tiam1/Rac1 complex with
the Sos1 DH/PH domains. a, The Tiam1/Rac1 complex. Switch
regions of Rac1 are red; the rest of the G protein is green.
Tiam1 DH and PH domains are yellow and blue, respectively;
disordered regions are orange; and black dashed line highlights
9
and its equivalent in Sos1 (c). b, View in a rotated 90° about
the horizontal. c, Structure of the Sos1 DH (yellow) and PH
(blue) domains15 aligned with Tiam1 orientated as in a by least
squares superposition of the 72 -carbon
atoms of CR1-CR3 (r.m.s. deviations, 1.52 Å). Yellow dashed line
indicates disordered residues in the Sos1 DH domain. d, View in
c rotated 90° about the horizontal. Note, position of the Sos1
PH domain overlaps the G-protein-binding interface. Figures 2, 5
and 6c were made using MOLSCRIPT40 and Raster3D^41.
The above figure is reprinted
by permission from Macmillan Publishers Ltd:
Nature
(2000,
408,
682-688)
copyright 2000.
9
and its equivalent in Sos1 (c). b, View in a rotated 90° about
the horizontal. c, Structure of the Sos1 DH (yellow) and PH
(blue) domains15 aligned with Tiam1 orientated as in a by least
squares superposition of the 72