Figure 2.
Figure 2. Schematic views of the PEX5 -PTS1 complex. a, A
view down the long axis of the peptide (ball-and-stick, in red).
TPRs 1 -3 are shown in yellow, TPRs 5 -7 in cyan, the hinge
region ('TPR4') in green, and other regions in white. b, A view
rotated 90° from (a). c, Stereo view of the C trace
of the complex, in the same orientation as (a). Peptide is in
red. d, Schematic representation of crystal packing if peptide
binding occurs by TPR clusters from the same receptor molecule.
TPRs 1 -3 are represented by the oval; TPRs 5 -7 by the
rectangle. The white bar represents the peptide binding site. e,
Similar diagram as in (d), showing crystal packing if peptide
recognition occurs by TPR clusters from neighboring molecules.
Dashed lines in (a,b) and (d,e) indicate the potential path of
the protein chain for which no electron density was observed.
Molecular representations in (a -c), as well as Fig. 4a,b, were
generated using MOLSCRIPT33.
The above figure is reprinted
by permission from Macmillan Publishers Ltd:
Nat Struct Biol
(2000,
7,
1091-1095)
copyright 2000.
trace
of the complex, in the same orientation as (a). Peptide is in
red. d, Schematic representation of crystal packing if peptide
binding occurs by TPR clusters from the same receptor molecule.
TPRs 1 -3 are represented by the oval; TPRs 5 -7 by the
rectangle. The white bar represents the peptide binding site. e,
Similar diagram as in (d), showing crystal packing if peptide
recognition occurs by TPR clusters from neighboring molecules.
Dashed lines in (a,b) and (d,e) indicate the potential path of
the protein chain for which no electron density was observed.
Molecular representations in (a -c), as well as Fig. 4a,b, were
generated using MOLSCRIPT33.