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Figure 2.
Fig. 2. Plot of backbone amide 15N T[1], T[2], and
heteronuclear 15N{1H}-NOE values versus residue number for
wild-type Cdc4p. The N and C termini and the linker region
connecting the two domains of the protein exhibit conformational
flexibility on a sub-nanosecond time scale as indicated by
anomalously high T[2] and low heteronuclear NOE values. Residues
within the loop regions, particularly between helices A and B
and helices E and F, also show evidence of conformational
mobility. The positions of the eight helices are indicated above
the figure with cylinders.
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