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Figure 2.
Figure 2. Space filling representation and stereo view of the
protein 4.1R core domain showing the binding regions for band 3,
glycophorin C/D, p55 and CaM. The color code for the binding
regions of band 3, glycophorin C/D, p55 and CaM is the same as
that used in Fig. 1d. a, Space filling representation of the
surface of the protein 4.1R core domain. Negatively charged
residues from the GPC binding region and positively charged
residues from the p55 binding region are colored in a darker
hue. Key amino acid residues that have been shown to be critical
for CaM binding are labeled: Ser 185 in the Ca^2+ sensitive CaM
binding region; and Trp 268, Phe 277, and Phe 278 in the Ca^2+
insensitive CaM binding region. Tyr 41 from the band 3 binding
sequence and Glu 246 from the p55 binding region are also
labeled. b, Space filling representation viewed from the
opposite side of the molecule shown in (a). Asp 216 and Glu 246
from the p55 binding region are labeled. c, Stereo view in the
same orientation as that in (a). Binding regions for band 3,
glycophorin C/D, and p55 are displayed in a translucent space
filling representation while CaM binding regions are presented
as ball-and-stick models. The Ca^ 2+ sensitive CaM binding
sequence (red) is organized in an extended structure while the
Ca^2+ insensitive CaM binding sequence (yellow) shows  -helical
structure.
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