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Figure 2.
Fig. 2. Overall structure of the Smad2 MH2 domain in complex
with a SARA SBD. (A) The schematic representation on the right
panel is related to the one on the left by a 90° rotation
along the horizontal axis. Smad2 and SARA are shown in green and
pink, respectively. The secondary structural elements in SARA
and some prominent features in Smad2 are labeled and
color-coded. (B) Sequence of the SARA SBD showing its secondary
structural elements. The bar graph below sequence shows the
buried surface area per SARA residue upon complex formation. The
residues that are targeted by inactivating mutations are
highlighted in red (Fig. 1C). (C) Superimposition of the
structures of the MH2 domains in Smad2 (green) and Smad4 (red),
shown in stereo view. The disordered loop between helices H3 and
H4 in Smad4 is indicated by a red dotted line. This figure was
prepared with MOLSCRIPT (24).
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