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Figure 2.
Fig. 2. A molecular surface representation of the interface in
the Ad12 knob-CAR D1 complex. (A) Sequence conservation surface
diagram of two knob monomers viewed at the CAR interface. The
molecules are colored on a sliding scale from white (conserved)
to red (nonconserved). Conservation analysis was based on an
alignment of all human Ad knob sequences available in GenBank. A
white strip of conservation transects the surface of the
molecule. Upon binding, the CAR D1 molecule occludes the
conserved strip on Ad12 knob. (B) Surface diagram of two
adjacent Ad12 knob monomers shown in the same view as (A). The
molecules are colored on a sliding scale from yellow (contact)
to red (no contact). Atoms in contact with CAR D1 are shared
between monomers. (C) Surface diagram of CAR D1. The molecules
are colored on a sliding scale from magenta (contact) to cyan
(no contact). This figure was generated with GRASP (30).
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