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Figure 2.
Figure 2. (a) A stereo view of the cleaved a[1]-antitrypsin
dimer with a s[A]-weighted omit map, contoured at four times the
r.m.s. of the map, for the region extending from P15 to P5',
shows the unequivocal nature of the dimer contact. Continuous
density is observed for the entire length of strand 4A of the
black monomer into strand 1C of the next monomer in green. Weak
density is observed at the site of cleavage. (b) A close-up of
the omit map at the site of cleavage. P15 to P7 is in black with
P6* to P5'* of the dimer partner in green. The omit map was
computed after refinement using the model of cleaved
a[1]-antitrypsin with the reactive centre loop (P15-P5') removed.
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