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Figure 1.
Figure 1. Views of the complex between Cdc42 and the wild type
Cdc42GAP. a, A ribbon diagram of the overall complex; Cdc42
is in yellow, Cdc42GAP is in blue. The disulfide bridge is in
green. GDP, the Mg^ 2+ ion, the nucleophilic attacking water and
the AlF[3] molecule are shown in ball-and-stick representation.
The switch I and II loops of Cdc42 are highlighted. The
catalytic arginine (Arg 305) from Cdc42GAP and the highly
conserved Gln 61 from Cdc42 are also shown. b, Ribbon diagram of
the C-terminal domain of Cdc42 in complex with Cdc42GAP. This
domain is stabilized by the disulfide bridge between Cys 105 and
Cys 188 and by the hydrogen-bond interactions between the side
chains of Arg 187 and Asp 76 (represented by two dotted lines).
Figures were prepared using MOLSCRIPT^30 and Raster3D^31.
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