Figure 1.
Figure 1 The INK4 inhibitors bind to one side of the
catalytic cleft of Cdk6, and interact with both the N and C
lobes. a, b, Schematic representation of the p16-Cdk6 complex in
two orthogonal views, with the ankyrin repeats numbered. c, View
of the p19-Cdk6 complex in an orientation equivalent to that in
b. Figures were made with the programs MOLSCRIPT50 and
RASTER3D^51.
The above figure is reprinted
by permission from Macmillan Publishers Ltd:
Nature
(1998,
395,
237-243)
copyright 1998.
