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Figure 1.
The overall structure of asymmetric activated FGFR1 kinase
dimer and detailed views of inter receptor contacts. (A)
Asymmetric dimer of active phosphorylated FGFR1 is shown in
ribbon diagram. Molecules E and S of the asymmetric dimer are
colored in cyan and green, respectively. (B) A detailed view of
the interface formed between kinases in the asymmetric dimer.
ATP analog (AMP-PCP) and interacting residues are shown in stick
representation and the magnesium ion is shown as a blue sphere.
Residues from molecule S are labeled with primes. The color
scheme applied in this figure is used for all figures. Secondary
structures are labeled in blue. (C) Surface representation of
molecule E is depicted in cyan with interacting residues of the
molecule S in stick and ribbon representation. Representative
residues from molecule S are labeled. (D) Surface representation
of molecule S is shown in green with interacting residues of
molecule E (Pale Cyan) in stick and ribbon representation
(www.pymol.org).
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