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Figure 1.
(a) Representation of the dimeric MV-H–CD46 complex present
in the asymmetric unit of the crystals. Ribbon drawings of the
MV-H molecules are shown with a rainbow coloring scheme, whereas
Cα traces of the CD46 molecules are shown in blue. The six
β-sheets building the MV-H β-propeller domain are labeled. The
C-terminal residues of the molecules, shown as spheres, are
followed by a polypeptide stalk in the full-length MV-H protein
or the SCR3 and SCR4 domains in the CD46 molecule. Putative
location of the virus and cell membranes are shown. (b) Detailed
view of the MV-H–CD46 interface. Two side views, differing by
120°, are shown. CD46 residues buried by the interaction
with MV-H are shown with spheres colored in dark blue (contact
region 1, the D′D loop of SCR1), magenta (contact region 2,
the SCR1-SCR2 interdomain region) and light blue (contact region
3, residues at SCR2).
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