Figure 1.
(a) Structure of TAB2 (red, zinc as yellow sphere coordinated
by orange cysteine residues) bound to diubiquitin (green, distal
Ub; cyan, proximal Ub). Ile44, Val70 and Leu8 are shown as blue
sticks. 2|F[0]| – |F[c]| electron density at 1 covers
Gly75, Gly76 and Lys63. (b) Selected residues of TAB2
interacting with ubiquitin are shown in orange. Dotted lines
indicate hydrogen bonds. (c) Arrangement of diubiquitin
complexes in the crystallographic lattice; two asymmetric units
are shown. A dotted line indicates where the continuous chain
can form. A schematic illustrates how the triubiquitin complex
is arranged in the crystal lattice.
The above figure is reprinted
by permission from Macmillan Publishers Ltd:
Nat Struct Biol
(2009,
16,
1328-1330)
copyright 2009.
covers
Gly75, Gly76 and Lys63. (b) Selected residues of TAB2
interacting with ubiquitin are shown in orange. Dotted lines
indicate hydrogen bonds. (c) Arrangement of diubiquitin
complexes in the crystallographic lattice; two asymmetric units
are shown. A dotted line indicates where the continuous chain
can form. A schematic illustrates how the triubiquitin complex
is arranged in the crystal lattice.