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Figure 1.
Figure 1. Structure of Pol γ
(A) Structure of Pol γA.
The pol domain shows a canonical “right-hand” configuration
with thumb (green), palm (red), and fingers (blue) subdomains
and the exo domain (gray). The spacer domain (orange) presents a
unique structure and is divided into two subdomains. Domains are
shown in a linear form where the N-terminal domain contains
residues 1–170; exo, 171–440; spacer, 476–785; and pol,
441–475 and 786–1239. All figures are made with Pymol
(DeLano, 2002).
(B and C) Structure of the heterotrimeric
Pol γ holoenzyme containing one catalytic subunit Pol γA
(orange) and the proximal (green) and distal (blue) monomers of
Pol γB. Pol γA primarily interacts with the proximal monomer
of the dimeric Pol γB.
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