|
Figure 1.
Figure 1: Structure of Pol II–B complex. a, B domain
organization and sequence conservation in the region connecting
the B-ribbon and B-core. Yellow and green highlighting indicates
conserved and invariant residues, respectively, between yeast
(S. cerevisiae), human (Homo sapiens) and the archaeon P.
furiosus (Pfu). b, Ribbon model of B as observed in its complex
with Pol II. A peak in the anomalous difference Fourier
(magenta) defines the zinc ion position (cyan sphere) in the
B-ribbon. The view is from the side. c, Overview of the Pol
II–B structure. Ribbon model with Pol II in silver and B in
colours as in a. Side and front views are used. Pol II domains
that interact with B are highlighted (dock, wheat; wall, blue;
flap loop, light blue; clamp with coiled-coil, red; rudder,
salmon; lid, dark red). The left view is from the side and lacks
most of Rpb2, including the protrusion. The right view is from
the front and includes Rpb2.
|
