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Figure 1.
Fig. 1. Comparison of the domain structure of kindlins and
the talin head. (a) Schematic diagram of the domain structure of
kindlins and talin. The individual domains—F1, F2, and
F3—that make up a canonical FERM domain are shown in green,
orange, and blue, respectively; the F0 domain is shown in red.
The kindlin PH domain is indicated by a black box. Unstructured
regions including the F1–loop region are shown in white. The
position of the long C-terminal talin rod is indicated. The
horizontal scale in both schematics is the same. (b) The primary
sequences of mouse kindlin-1 and talin-1 FERM domains were
aligned by T-Coffee. The same color scheme is used as in (a).
The sequence of the F1 insert and the kindlin PH domain are not
included in the alignment. The six tryptophan residues in
kindlin-1 F0 are shown in bold. The overall similarity between
talin-1 and kindlin-1 is relatively low (28%), due largely to
the inclusion of the kindlin PH domain and the insert in F1. The
similarity between the individual F0, F1, F2, and F3 domains is
much higher (36–55%).
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