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Figure 1.
A, the co-crystal structure of MEL5 (α chain shown as a
yellow schematic diagram, β chain shown as a salmon schematic
diagram) bound to the HLA-A*0201 (shown as green and blue
schematic diagrams) molecule complexed with the ELAGIGILTV
peptide (shown as blue sticks). B, expanded view of the
interface between the MEL5 variable domain bound to the A2-ELA
surface (colors as in A). The overall conformation of the
ELAGIGILTV peptide (N to C terminus, left to right), including
the central peptide bulge, is displayed. C, view from above of
the MEL5 CDR loops bound to the A2-ELA surface (colors as in A;
MEL5 CDR loops shown as spheres). The MEL5 TCR binds toward the
N terminus of the peptide, making contacts with the peptide via
its CDR1 and CDR3 loops and contacts with the MHC surface via
its CDR1 and CDR2 loops.
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