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Figure 1.
Figure 1. Ligand Binding Site of the Purine Riboswitch and
Chemicals
(A) Details of hypoxanthine (top, PDB 1U8D) and
adenine (bottom, PDB 1Y26) bound to the guanine and adenine
riboswitches, respectively. The specificity pyrimidine (C74 or
U74, yellow) forms hydrogen bonds (red dashed lines) to the
Watson-Crick face of the ligand (pink), whereas U51, U47, and
U22 interact with the other faces of the purine nucleobase.
Residues are colored according to their strand position in the
junction region. Note that the hydrogen bonding pattern for
ligand recognition is identical.
(B) Chemical structures of
purine derivatives characterized in this study.
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