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Figure 1.
Structure of the talin 1655–1822 rod domain. A, schematic
representation of the domain structure of talin indicating the
relative position of the ligand binding sites and the boundaries
of the various head and rod domains. B, sequence alignment of
human talin1 residues 1655–1822 with the corresponding regions
of other talins. C, superimposition of the 20 lowest energy
structures consistent with the NMR data. Only the structured
region of 1655–1822 is shown, not the disordered N terminus.
D, ribbon drawing of a representative low energy structure
showing the overall topology of the five-helix bundle. E, map of
the surface charge of the domain.
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